Development of Dual-Targeted Mixed Micelles Loaded with Celastrol and Evaluation on Triple-Negative Breast Cancer Therapy

Considering that the precise delivery of Celastrol (Cst) into mitochondria to induce mitochondrial dysfunction may be a potential approach to improve the therapeutic outcomes of Cst on TNBC, a novel tumor mitochondria dual-targeted mixed-micelle nano-system was fabricated via self-synthesized triphenylphosphonium-modified cholesterol (TPP-Chol) and

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(3-Ammonio-2,2-dimethyl-propyl)carbamate Dihydrate

(3-Ammonio-2,2-dimethylpropyl)carbamate dihydrate was synthesised.The title compound was characterised by single crystal X-ray In Ground Product (Heaters) diffraction and IR-/Raman-spectroscopy.It has been demonstrated that a mixture of dilute acetic acid and 2,2-dimethyl-1,3-diaminopropane is able to capture CO2 spontaneously from the atmosphere.A

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